vitamin b12 deficiency in diabetic patients
2013;71:38690, 12. Aims To compare the prevalence of vitamin B12 deficiency and peripheral neuropathy between two groups of type 2 diabetes mellitus (T2DM) patients treated with or without metformin, and to determine factors associated with vitamin B12 deficiency therapy and dietary intake of vitamin B12. This issue maybe debatable to some, but we think that there is a need for physicians to keep abreast with the latest recommendations and guidelines pertaining to management of diabetes. Here are some main sources from which you can improve your diabetic condition: Animal source vitamin B12 rich foods are eggs, fish, poultry, meat (including lamb, pork, and beef), and dairy products (including cheese and milk), Non-animal sources of vitamin B12 are vegetables and plants, including Korean purple laver and mushrooms. [2] The prevalence of diabetes in Saudi Arabia alone has increased to reach 7 million cases. Further research is needed to confirm the need for routine There is a need to inject diabetic patients with a dose of 1mg. 14-16 In addition, previous studies have shown that circulating folate concentrations are significantly lower in patients with T2D compared with healthy individuals. You may search for similar articles that contain these same keywords or you may You can boost the absorption of vitamin B12 in your body by taking the following medications: 1- An antibiotic- known as chloramphenicol. While in anemia, the number of healthy red blood cells to carry out oxygen depletes. [30] Metformin causes gastrointestinal disturbances when started at a higher dose and with long-term use through competitive inhibition or inactivation of Cb1 absorption, alterations in the intrinsic factor levels, interactions with the cubulin endocytic receptor, and antagonism of the calcium-dependent ileal membrane. Clinical, anthropometry and laboratory data were collected. Taylor & Francis does not sell reprints or permissions for this article. Estimation of Serum Vitamin B12 Levels Among the Elderly Population of Wardha City: A Cross-Sectional Study. suggested that the mechanism for this vitamin B12 deficiency is caused by the slowed intestinal transit time among diabetics causing bacterial overgrowth and eventually B12 malabsorption. Vitamin B12 deficiency was found in 96 (49.1%) of the patients. Dr. Braden G. Barnett is an endocrinologist in Los Angeles, California and is affiliated with multiple hospitals in the area, includingKeck Medical Center of USCandUSC Norris Comprehensive Cancer Center. [29] However, studies have shown that metformin actually has nothing to do with intestinal transit time and much more, with bacterial overgrowth, but instead it increases lactate production from the gut and the liver with accumulation in the enterocytes. (10.1136/bmj.c2181) [24] Although vitamin B12 deficiency is a common but not serious condition, it is deemed important to treat patients to avoid neurological impairment even if there may be discordance between the results and clinical features. Vitamin B12 deficiency resulting from metformin use has been demonstrated in multiple studies. People also read lists articles that other readers of this article have read. Front Microbiol. other information we have about you. Hunt A, Harrington D, Robinson S. Vitamin B12 deficiency Bmj. Biochemical and clinical vitamin B12 deficiency has been demonstrated to be highly prevalent among patients with type 1 and type 2 diabetes mellitus. Sharma R, Wanjari MB, Raut A, Gujar S, Gledina A, Kantode VV, Munjewar PK. Lets discuss vitamin B12 deficiency, its reasons, and why its deficiency is serious for diabetes patients. WebA B12 supplement can be helpful if you have type 2 diabetes and are deficient in the vitamin. We use cookies to improve your website experience. 1 The prevalence of vitamin B12 deficiency in diabetes mellitus 3099067 Diabetes: Fact sheet [Internet]. Conclusions: 2016;59:42635, 30. This vitamin is essential for the proper functioning of the body. Approvals were taken from the directors of the four hospitals prior to data collection. 2014;29:1394400, 18. Association of vitamin B12 deficiency and metformin use in patients with type 2 diabetes J Korean Med Sci. https://www.uptodate.com/contents/search. Your message has been successfully sent to your colleague. 2016;42:31627, 15. Metformin; type 2 diabetes; Vitamin B12 deficiency; Vitamin B12 screening; Vitamin B12 supplementation. Liu KW, Dai LK, Jean W. Metformin-related vitamin B12 deficiency Age Ageing. (10.1007/bf00427979) Natural Medicines. When you do not treat your vitamin B12 deficiency, you may face severe diabetic complications. Routine testing for serum vitamin B12 level is not practiced in our institution. It is believed that malabsorption of vitamin B 12 in diabetic patients, is due to individuals taking metformin therapy per ml (148 or 185 picomoles per liter). Table 5 shows the demographic profile of the 100 respondents. 2012;35:32733, 9. Wolters Kluwer Health The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). In both diabetes type 1 and type 2, diabetic patients experience its deficiency. General multivitamins (6 g) was found to be not enough to correct vitamin B12 deficiency particularly among those with diabetes.[8]. Registered in England & Wales No. [2] In 2015, diabetes was the leading cause of 1.6 million deaths and World Health Orgnization projects that diabetes will be the seventh most important cause of death by 2030. If you face a serious problem maintaining glucose, taking a vitamin B12 injection for almost 3 months will help you bring things in balance. There are various vitamins of group B which are effective in lowering blood sugar levels. Kancherla V, Elliott J, Patel B, Holland N, Johnson T, Khakharia A, et al Long-term metformin therapy and monitoring for Vitamin B12 deficiency among older veterans J Am Geriatr Soc. Another serious thing that may happen to vitamin B12 deficient people is loss of smell and taste sensations. There are a few different options as far as how you can treat your vitamin b12 deficiency if you are diabetic. Using metformin therapy for a long time is a cost-effective and practical treatment of blood glucose level maintenance. Generally, vitamin B12 supplements start showing their effect after 48 to 72 hours of the initial dose. Table 2: Factors associated with Vitamin B12 deficiency among patients with diabetes at Princess Marina Hospital diabetes clinic, between July 2017 and October 2017. Type 2 Diabetes Vitamin B12 Deficiency Hyperhomocysteinemia: Due to high cost for investigation serum homocysteine level was measured only in 6 patients and serum vitamin B12 level (cheaper test) was measured in 14 patients with prior permission from Ethics Committee. This can happen if you don't eat The use of vitamin B12 supplement was significant among patients 46 years old and above [Table 4]. A single copy of these materials may be reprinted for noncommercial personal use only. Due to deficiency of B12 vitamin, the level of blood glucose decreases. Please try again soon. Aust Fam Physician. For one, this study was done retrospectively, thus the vitamin B12 status of the patients was all based on the medical records, and for this reason vitamin B12 levels were not available. Federal government websites often end in .gov or .mil. 2012;122:25370, 5. Epub 2021 Nov 24. Make sure to take a regular intake of this vitamin for diabetes and treatment of other diseases. You might be thinking about how you can take vitamin B12 naturally when you are a vegetarian. [4] Both American and European guidelines recommend metformin as the first-line agent for the pharmacological management of T2DM. -. Vitamin deficiency anemia is a lack of healthy red blood cells caused by lower than usual amounts of vitamin B-12 and folate. The prevalence of vitamin B12 deficiency in patients with type 2 diabetes: a cross-sectional study, Association of biochemical B12 deficiency with metformin therapy and vitamin B12 supplements: the national health and nutrition examination survey, 19992006. This site needs JavaScript to work properly. A multi-cluster random sampling technique was used. Search for Similar Articles Unauthorized use of these marks is strictly prohibited. It is because diabetics mostly take metformin, which is a well-known treatment of Type-2 diabetes. There are a few different options as far as how you can treat your vitamin b12 deficiency if you are diabetic. The prevalence of vitamin B12 deficiency was 6.6%. Metab., 101 (2016), pp. You may also suffer from diabetic neuropathy due to a lack of vitamin B12. Treatment Of B12 Deficiency In Diabetes Patients. T2DM is a significant risk factor to the development of ischemic stroke. Vitamin B12 deficiency in patients with . https://doi.org/10.1080/16089677.2021.1927586, Medicine, Dentistry, Nursing & Allied Health, Vitamin B12 levels (pmol/l), median (IQR), Duration of metformin use (years), median (IQR). This outpatient cross-sectional study found 6.6% of patients with diabetes at Princess Marina Hospital diabetes clinic to be vitamin B12 deficient. 2022;74(7):2373-2383. doi: 10.1080/01635581.2021.2007271. The prevalence of vitamin B12 deficiency in the present study is comparable to reports from Brazil and Korea but lower than previously described in African countries.Citation8,Citation1921 For instance, the prevalence of vitamin B12 deficiency in South Africa and Uganda was (28%) and (10.7%), respectively.Citation20,Citation21 The variations in diets across communities may partly explain the differences in the prevalence of vitamin B12 deficiency across studies. Vitamin B12 deficiency is highly prevalent, especially in patients with diabetic neuropathy. Michalak SS, Wolny-Rokicka E, Nowakowska E, Michalak M, Gil L. J Diabetes Res. National Library of Medicine 2021 Nov 26;9(33):10198-10207. doi: 10.12998/wjcc.v9.i33.10198. 2014;127:816, 23. Accessed Jan. 9, 2021. Such patients are also more vulnerable to pernicious Armenia. PMC He received his medical degree from University of Southern California and has been in practice around 8 years. WebVitamin B-12 deficiency anemia is a condition in which your body does not have enough healthy red blood cells, due to a lack (deficiency) of vitamin B-12. Diabetes Care 2012. WebKey points about vitamin B12 deficiency anemia. 8600 Rockville Pike https://www.micromedexsolutions.com. The mean serum vitamin B12 level of all 16 patients was 558.46 318.01 pg/mL (range of 1741288 pg/mL). [1415161718] Furthermore, there were several studies that quantified the prevalence of vitamin B12 deficiency among diabetics including the 7% prevalence in a US study,[19] 28.1% prevalence in a South African study,[20] 22.5% in Brazil,[21] 18.7% in New Zealand,[22] 9.7% in the Netherlands,[7] and 9.7% in Libya. However, older adults, vegetarians, vegans and people who have conditions that affect their ability to absorb vitamin B-12 from foods might benefit from the use of oral supplements.
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